Misha Angrist, Assistant Professor of the Practice, Institute for Genome Sciences & Policy, Marc Salit, Research Chemist, NIST, Dorit Berlin, Principal Investigator, National Institute of General Medical Sciences Human Genetic Cell Repository; Principal Investigator, Congenital Heart Disease Genetic Network Study Biorepository, and Robert Krulwich, Science Correspondent, NPR; Co-host, NPR's "Radiolab", discuss choosing to be a human reference standard for the human genome project.
Misha Angrist is Assistant Professor of the Practice at the Duke University Institute for Genome Sciences & Policy. He holds a PhD degree in Genetics from Case Western Reserve University, an MFA in Writing and Literature from the Bennington Writing Seminars, and was formerly a board-eligible genetic counselor. He has covered the biotechnology industry as market-research analyst and worked as an independent life sciences consultant, writer and editor.
In April 2007 he became the fourth subject in Harvard geneticist George Church's Personal Genome Project and in 2009 had his full genome sequenced at Duke. His book, Here is a Human Being: At the Dawn of Personal Genomics, will be published in the fall by Harper Collins.
Dorit S. Berlin, Ph.D., is principal investigator of the NIGMS Human Genetic Cell Repository, a large biobank funded by the National Institute of General Medical Sciences that focuses on heritable disorders and houses more than 11,000 cell line and nucleic acid samples at the Coriell Institute for Medical Research. Dorit is also principal investigator of the Congenital Heart Disease Genetic Network Study Biorepository, which is funded through the National Heart, Lung, and Blood Institute. Prior to joining Coriell, Dorit was a postdoctoral scholar at Stanford University, where she worked on scientific curation for the Pharmacogenomics Knowledge Base. Dorit also founded and led an education project to create a web-based pharmacogenomics teaching module and implement it as an online exhibit for the Tech Museum of Innovation in San Jose, CA. Dorit earned her undergraduate degree in chemistry from the Massachusetts Institute of Technology and her doctorate in molecular and cell biology from the University of California, Berkeley.
Robert Krulwich covers science for National Public Radio and is Co-host of NPR's "Radiolab." His specialty is explaining complex subjects—science, technology, economics – in a style that is clear, compelling and entertaining. For several decades he was a correspondent at ABC and CBS News plus he hosted PBS’ Frontline, Nova Science Now and a BBC cultural show, "The Edge." TV Guide called him "the most inventive network reporter in television." He has explored the structure of DNA with a banana, created his own Italian Opera "Ratto Interesso" to explain how the Federal Reserve regulates interest rates, he pioneered the use of new animation on ABC's Nightline, World News, and on NPR's Internet site to explore cellular biology and subprime lending.
Marc Salit is leading a group at the National Institute of Standards and Technology (NIST) dedicated to technology development and measurement infrastructure (standards, reference data, predictive models) for massively multiplexed genome-scale measurement methods. This "Multiplexed Biomolecular Science" group is a multidisciplinary team growing out of work to address microarray measurement science issues, and a long-running effort in technology and measurement science in microfluidics. Marc has worked extensively in measurement science in chemistry and physics, with emphasis on precision measurements, lab automation, algorithm development, measurement uncertainty, traceability, and standards development. His research is now focused on bringing experience from the chemical metrology community to the emerging biometrology community.